Tests using phenosulfonphthalein as diagnostic agent: decreased urinary excretion of phenosulfonphthalein Urine protein: increased levelĭrug-food. Pregnancy test, protirelin-induced thyroid stimulating hormone, radionuclide thyroid imaging, serum theophylline (Schack and Waxler method), urine catecholamines, urine glucose, urine hydroxyindoleacetic acid, urine ketones (ferric chloride method), urine vanillylmandelic acid: test interference Alanine aminotransferase, alkaline phosphatase, amylase, aspartate aminotransferase, coagulation studies, PaCO 2, uric acid: increased valuesĬholesterol, glucose, potassium, protein-bound iodine, sodium, thyroxine, tri-iodothyronine: decreased levels Tetracycline (oral): decreased absorption of tetracycline (with buffered aspirin)ĭrug-diagnostic tests. Sulfonylureas (such as chlorpropamide, tolbutamide): enhanced sulfonylurea effects Spironolactone: decreased spironolactone effect Methotrexate: decreased methotrexate excretion and increased blood level, causing greater risk of toxicity Nizatidine: increased salicylate blood level Acidifying drugs (such as ammonium chloride): increased salicylate blood levelĪctivated charcoal: decreased salicylate absorptionĪlkalinizing drugs (such as antacids): decreased salicylate blood level Angiotensin-converting enzyme (ACE) inhibitors: decreased antihypertensive effectĪnticoagulants, NSAIDs, thrombolytics: increased bleeding riskĬarbonic anhydrase inhibitors (such as acetazolamide): salicylismĬorticosteroids: increased salicylate excretion and decreased blood level Furosemide: increased diuretic effect Live varicella virus vaccine: increased risk of Reye's syndrome Maintenance dosage is 3 to 10 mg/kg/day given as a single dose for up to 8 weeks or until platelet count and erythrocyte sedimentation rate return to normal.Īdults: 325 to 650 mg P.O. ➣ To reduce the risk of myocardial infarction (MI) in patients with a history of MI or unstable anginaĬhildren: Initially during acute febrile period, 80 to 180 mg/kg/day P.O. ➣ To reduce the risk of transient ischemic attacks (TIAs) or cerebrovascular accident in men with a history of TIAs caused by emboliĪdults: 650 mg P.O.
in individual doses for first 2 weeks then maintenance dosage of 75 mg/kg/day P.O. in divided dosesĬhildren: Initially, 100 mg/kg/day P.O. give in divided doses q 6 to 8 hours.Īdults: 5 to 8 g/day P.O. daily in children weighing more than 25 kg P.O. in children weighing 25 kg (55 lb) or less, or 2,400 to 3,600 mg P.O. in divided doses, to a maximum dosage of 6 g/day.Ĭhildren: 60 to 130 mg/kg/day P.O.
Usual maintenance dosage is 3.6 to 5.4 g/day P.O. Dosage may be increased by 325 to 1,200 mg daily at intervals of at least 1 week. ➣ Mild to moderate pain caused by inflammation (as in rheumatoid arthritis or osteoarthritis)Īdults: Initially, 2,400 to 3,600 mg P.O.
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